Cannabidiol Gel For Fragile X Syndrome and Epilepsy

Zygel, a novel cannabidiol-gel, is designed for transdermal delivery. The combination of permeation enhancements allows for controlled drug delivery to bloodstreams. It minimizes the risk from negative psychoactive effects. It is currently being developed for patients suffering from fragile X syndrome (FXS), epilepsy, or both. Phase 2 is an open-label study. In the past, cannabidiol had been used in adults with focal epilepsy. Recent research showed that it was an effective treatment for this group with consistent results across all treatment groups. But, safety is still a concern.

Currently, there is no FDA-approved cannabinoid medication for these patients. Alternative therapies are being studied to determine if they can lower seizures, improve quality of life, or reduce comorbidities. Transdermal gels may be an option as they do not cause THC to be broken down in the stomach acid.

ZYN002 was conducted to determine the safety and efficacy cannabidiolgel gel. It's a double-blind placebo-controlled clinical trial that evaluated the safety and efficacy at two dose levels of the gel. Participants with severe autism spectrum disease were given ZYN002 250 mg or 500mg daily. Participants with severe autism spectrum disorder were evaluated on their quality of lives, sleep, quality of life and scores.

At week 4, patients with baseline pain scores higher than 7 had greater pain reductions than the placebo group. The mean seizure frequency reduction in the treatment group was 12.3%, according to the seizure frequency scores. Similarly, tonic-clonic seizures were reduced by 57.5%, compared to a 48% reduction in the placebo group.

RECONNECT is currently being conducted in clinical locations in Australia, Ireland, and the United States. It is an open-label extension for the CONNECT - FX trial. Participation is available to about 240 patients. The trial is open to patients aged 3-17 years. They must have been diagnosed with DEE and have had at least three seizures per day. Upon completion of the study, participants will be discharged from the study.

The BRIGHT study evaluated the effectiveness of ZYN002 in adolescents with autism spectrum disorder. Results were presented at 14 months. The results showed that ZYN002 reduced abnormal behavior and improved irritability among participants. The results also showed an improvement in alertness, sleep, and general well-being. Parents and caregivers also reported an increase in social engagement and energy. Although the trend was not statistically significant it did not have a significant impact on the overall population.

Zygel was very well tolerated. Although there were many treatment-related adverse effects reported by patients, the most common ones were mild and moderate. The safety of the study was also determined by an independent laboratory. Many of these AEs were mild and not serious, with only one case reporting diarrhea.

The study is considered pivotal. The company plans to complete a New Drug Application for Fragile X Syndrome. Several other studies are also being conducted to further evaluate the effectiveness of cannabidiol.

FAQ

What are some common blunders that companies make when they venture into the US cannabinoid markets?

It is easy to make a mistake by not knowing the regulations surrounding cannabis products. This could result in you needing to alter your product formulation.

Another mistake is not being able to correctly label your product. Know whether your product contains THC, CBD or both.

The third thing you need to do is understand how to package your product properly. You must make sure that your product contains THC.

If your product does not contain THC, then you should still follow all packaging laws because there are many states where cannabidiol (CBD) is legal.

Remember to keep track of any recalls for your products. Customers should be notified as soon as possible if there are any issues with their product.

Which CBD products are most popular?

CBD products are all over the place these days. These products are being used to treat everything, from anxiety to pain relief. The market is growing rapidly and is very large.

But why do people purchase CBD? This is how it affects brand owners.

Statista reports that CBD products have relaxing properties. They are also used for their anti-inflammatory properties.

If your product contains both CBD and THC, it can be used for medicinal and recreational purposes.

But what about brands who are focused on one purpose only? One example is CBD for stress relief.

Furthermore, a brand who focuses on CBD-based medical uses will be able to attract a lot of customers.

However, if a brand wants to target recreational users, then they need to create a unique selling proposition (USP). A USP basically refers to a unique selling point that sets a brand apart.

For instance, some brands offer free shipping and others offer discounts on bulk orders.

How big does the global CBD market look?

According to Euromonitor International, the global CBD market was worth $US 3.5 Billion in 2015. This is more than 10% higher than 2014

The report predicts that this figure will grow by 12% annually to $US6.4 billion in 2020.

CBD products are expected to account for around half of all hemp-derived products sold globally by 2020.

This includes CBD oils, as well other CBD products, including food, beverages cosmetics, pet care, and CBD oils.

Where can I purchase CBD products?

CBD can be bought online or at your local retailer. You will find better deals at online retailers. Many websites sell CBD products containing industrial hemp.

Local shops are a good option if you prefer to shop locally.

There are laws in many states that allow CBD products to be purchased without the need of a prescription. You may be able buy CBD products from your local pharmacy if you are a resident of one of these states.

CBD products could even be delivered to your home.

Is CBD a good investment?

As more people are aware of the many benefits of hemp-based products and their market, it continues to grow. The market for hemp-based products could reach $1 billion by 2022, according to estimates.

It is also expected that the market will continue to grow at an annual rate exceeding 20% through 2020 when it reaches $2.5 Billion.

Hemp oil is already used in many beauty and health care products such as lotions, shampoos, lip balms, moisturizers, body butter, and skin creams.

Many companies also make CBD-infused snacks, pet food, treats, and other food products.

CBD is currently legal across all 50 states. But, this may change in the near future. More research into CBD's potential uses will be done, which will make it easier for businesses and law enforcement to do business legally.

These are all factors that make CBD investments a viable venture.

Statistics

• The inhibition of FAAH is predicted to lead to an increase in brain and plasma concentrations of AEA, which acts as a partial agonist at CB1R and CB2R, thereby increasing endocannabinoid tone [92, 110]. (ncbi.nlm.nih.gov)
• As a substance that was federally illegal before the passage of the 2018 Farm Bill, hemp-derived cannabinoids with no more than 0.3% THC still face a regulatory grey area. (forbes.com)
• OralWhere HED is the human equivalent dose, and Km is a correction factor estimated by dividing the average body mass (BM) of the species (60, 0.020, and 0.150 kg for 11 humans, mice, and rats, respectively) and by its surface area (see: Nair et al. (ncbi.nlm.nih.gov)
• The use of these products is likely to become even more widespread if the World Health Organization's recommendation that CBD no longer is scheduled in the international drug control conventions is adopted by the United Nations member states [201]. (ncbi.nlm.nih.gov)
• however, one study also found that these effects were virtually abolished when the original media (a nutrient broth agar) was replaced with one containing 5% blood (increasing the minimum concentration to ~160 μM CBD) [179]. (ncbi.nlm.nih.gov)

External Links

congress.gov

• H.R.2: 115th Congress (2017-2018). Agriculture Improvement Act of 2018.
• Library of Congress

sciencedirect.com

• CBD for the treatment of pain: What is the evidence? ScienceDirect
• Cannabidiol stimulates antioxidant pathways within keratinocytes through targeting BACH1 ScienceDirect

dea.gov

• Home
• DEA Announces Their Intent To Schedule Kratom

fda.gov

• FDA
• FDA approves First Drug Composed of an Active Ingredient Derived From Marijuana in Treatment of Rare and Severe Forms Of Epilepsy

How To

How to Sell CBD Oil at Home

CBD oil is a very popular product online. It is derived form hemp plants and has been used since ancient times to relieve pain and inflammation. It is a great product that can treat anxiety, depression, insomnia, chronic and other conditions. People are often hesitant to try CBD because they don't know how to get started. This article will give you some helpful tips for selling CBD oil at your home. You won't have to worry about legal issues.

Steps to Selling CBD Online

1. Check to see whether your state allows CBD oil sales. If your state doesn't allow the sale, then you can look for other states that do. Before starting any CBD-related business, you should consult your local health department.
2. Your site must comply with all FTC regulations. There are two types: sites that comply with FDA guidelines for CBD oil sales and those that don’t. Sites selling CBD oil have to adhere to the U.S. Food and Drug Administration rules. Without scientific evidence, they can't claim CBD oil helps with certain medical conditions. They must also keep detailed records of each transaction on their website.
3. A good understanding of CBD oil will help you understand its true meaning. Some people think that CBD means cannabidiol which is true; however, CBD can refer to anything extracted from the cannabis plant. Talking to your doctor is the best way to determine if CBD oil can help your condition.
4. You must decide whether you plan to sell wholesalers or retail. Wholesalers can buy large quantities of CBD oil to resell to retailers. Retailers purchase small amounts of CBD oil from wholesalers and then rebrand it for retail. Wholesale prices are often more expensive than retail.
5. Decide whether you wish to start a business that offers drop shipping. Drop shippers ship goods directly to customers, from their suppliers. They handle all aspects of delivering orders, customer service included. Dropshipping can be a great way to start a business, as it requires very little upfront investment.
6. Select a manufacturer. Many companies sell CBD oil as an alternate medicine. These manufacturers have different strengths and flavors available. A lot of these companies also offer free trials. Start looking around until you find a company that fits your needs.
7. Make a Facebook Page. Marketing plays an important role in social media. With Facebook alone, you can reach millions of potential customers. Register a page, and then post information about the new venture.
8. Promote your brand. Once you have a successful page on Facebook, start promoting your brand on other social networks such as Instagram or Twitter.
9. Sell your products. Once you have decided to sell CBD oils, you will need to decide which type of CBD oil product you want. Do you want to sell only drops or tinctures? What would your price per bottle be? What packaging would your company use?
10. Give a complete description of each product. Include all of the ingredients and any warnings that may be associated with using CBD oil.
11. List the prices of your products. Keep in mind that the price of your products will vary depending on the strength of the product. A 10ml container of 100mg CBD oil is $30; a 500mg CBD Oil bottle is $120.
12. Images will attract more attention. Post images of your products so that people understand what they are buying. You can even include videos if you wish.
13. Optimize the store. Your store should look professional and well-organized. If your store does not look its best, you might lose customers due to bad design.
14. There are many ways you can increase your online reputation. Google reviews are an essential part of people's search for products. Negative reviews can lead to customers being turned away.
15. Offer discounts. Many people do not like to pay full price for goods. Discounts can help you increase your profit.
16. Use email marketing. Email marketing allows to send promotional messages, to people who are interested in your products. This is a great method to build relationships between your customers.
17. Make sure your website is optimized. If you want to start a new business, it is essential that your website works properly. Your site should have useful information about products and services.
18. Help you manage your business. A business requires many tasks. If you do not employ someone to manage some of the work, it is a waste of time to learn how to complete those tasks.
19. Get started! Now that you've read this article, it is time to get started with your CBD Oil Business. Good luck!